- Selective adjuvant radiation therapy for distant lymph node metastasis in patients with stage 4B epithelial ovarian cancer: a case series
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Eun Taeg Kim, Seung Yeon Oh, Sun Young Ma, Tae Hwa Lee, Won Gyu Kim
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Kosin Med J. 2023;38(4):293-299. Published online December 20, 2023
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DOI: https://doi.org/10.7180/kmj.23.146
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Abstract
PDFPubReader ePub
- Although the efficacy of surgery followed by taxane- and platinum-based systemic chemotherapy has been clearly demonstrated in the standard first-line treatment of epithelial ovarian cancer, the role of radiation therapy for distant lymph node metastasis in patients with epithelial ovarian cancer is not well-established due to a lack of reported studies. We identified four patients who underwent selective adjuvant radiation therapy for neck and para-aortic lymph node lesions after primary debulking surgery between 2020 and 2022, followed by platinum-based chemotherapy for stage 4B high-grade serous ovarian cancer. Through a retrospective review of medical records, we analyzed patient clinicopathologic features, treatment course, and imaging findings. The median age was 49.25 years (range, 46–54 years). All patients had the International Federation of Gynecology and Obstetrics stage 4B disease. Following primary debulking surgery, all patients received weekly paclitaxel-carboplatin chemotherapy and maintenance treatment with poly(ADP-ribose) polymerase (PARP) inhibitors. All patients received selective adjuvant radiation therapy for neck and para-aortic lymph node metastasis before PARP inhibitor maintenance. The median follow-up time was 36.75 months (range, 19–45 months). All patients achieved a complete response. None of the patients experienced disease recurrence or died during the follow-up period. The management of distant lymph node metastasis in patients with epithelial ovarian cancer remains a matter of debate. Selective adjuvant radiation therapy in first-line treatment for ovarian cancer appears to be a feasible approach with maintenance therapy for stage 4B epithelial ovarian cancer.
- Genipin Inhibits Hypoxia-Induced Accumulation of HIF-1α and VEGF Expressions in Human Cervical Carcinoma Cells
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Cho Eui Jin, Jung Hyun Lee, Geun Joo Kim, Tae Hwa Lee
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Kosin Med J. 2019;34(2):106-116. Published online December 31, 2019
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DOI: https://doi.org/10.7180/kmj.2019.34.2.106
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Abstract
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Objectives
Hypoxia—a characteristic of almost all types of solid tumors—has been associated with poor outcomes in several human malignancies. Genipin—an active constituent of Gardenia fruit— has been reported to exert an anti-tumor effect in several cancers. In this study, we investigated inhibition of angiogenesis using Genipin-mediated hypoxia-induced hypoxia inducible factor (HIF-1) and VEGF expression in human cervical cancer cells.
Methods
Under normoxic and hypoxic conditions, the expression of HIF-1α and VEGF in cervical cancer HeLa cells was detected by quantitative reverse transcription polymerase chain reaction and western blotting. Luciferase reporter assays were used to investigate the molecular mechanisms underlying the hypoxia-induced survivin activation.
Results
Surprisingly, we found that Genipin suppressed the HIF-1α accumulation during hypoxia in human liver cancer cell line (HepG2), human prostate cancer cell line (LNCaP), colon cancer cell line (HCT116), and breast cancer cell line (MDA231). Genipin treatment also significantly reduced hypoxia-induced secretion of VEGF.
Conclusions
Suppression of HIF-1α accumulation following treatment with Genipin under hypoxia was associated with PI3K and MAPK pathways. Taken together, these results suggested that Genipin inhibits HIF-1α expression through inhibition of PI3K and MAPK signaling pathways. These results provide new insights into a potential mechanism of the anticancer properties of Genipin.
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Citations
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- Clinical Significance of HPV DNA Test for Follow up of Patients with Cervical Intraepithelial Neoplasm After LEETZ
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Mi Hyang Kim, Tae Hwa Lee, Young Lim Oh, Chun Jun Lee, Won Gyu Kim
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Kosin Med J. 2009;24(2):141-146. Published online December 31, 2009
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- A Case of Misplaced IUD
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Tae Hwa Lee, Sung Han Kim
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Kosin Med J. 2008;23(4):294-296. Published online December 31, 2008
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- Clinical Characteristics of Clear Cell Carcinoma of The Ovary
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Tae Hwa Lee
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Kosin Med J. 2008;23(2):52-57. Published online June 30, 2008
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- A Clinical Study of Borderline Malignant Tumors of the Ovary
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Tae Hwa Lee, Sung Han Kim
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Kosin Med J. 2008;23(2):58-65. Published online June 30, 2008
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- Lifetime and Age Conditional Probabilities of Reproductive Organ cancers in Women of Korea
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Min Jung Kim, Tae Hwa Lee, Sung Han Kim
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Kosin Med J. 2007;22(2):89-99. Published online December 31, 2007
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- A Case of Delivery in Severe Gestational Thrombocytopenia
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Tae Hwa Lee, Chun June Lee
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Kosin Med J. 2007;22(2):195-198. Published online December 31, 2007
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- A Case of Primary Signet Ring Cell Adenocarcinoma of Uterine Cervix
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Tae Hwa Lee, chun june lee, Sung Han Kim
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Kosin Med J. 2006;21(2):166-169.
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